Understanding the Science Behind Semaglutide

2024-01-12

ShedRx

Are you struggling with weight loss despite countless diets and exercise regimens? In a world where obesity rates continue to rise, finding effective solutions can be difficult. However, there’s hope on the horizon in the form of Semaglutide, a revolutionary weight-loss wonder drug that’s capturing the attention of both the medical community and individuals seeking a sustainable path to shedding excess pounds. Semaglutide represents a breakthrough in the battle against obesity, offering not only remarkable weight-loss results, but also improvements in overall health.

But how does Semaglutide work? Is it really effective or is it just another fad? This article explores the science behind weight loss and why most weight-loss diets eventually fail, followed by an exploration of the science behind Semaglutide injections for weight loss. We describe precisely why Semaglutide is a weight-loss wonder drug.

Weight Loss Is A Serious Health Concern

Obesity is not merely a cosmetic issue; it’s a severe health concern that affects millions of people worldwide. Beyond the challenges of fitting into your favorite clothes or feeling confident in your appearance, being overweight can have detrimental effects on your overall well-being.

The Rising Obesity Epidemic

In recent decades, the world has witnessed a startling increase in obesity rates. This global epidemic extends across all age groups and demographics, with alarming implications for public health. According to the World Health Organization (WHO), obesity has nearly tripled since 1975, with over 1.9 billion adults classified as overweight in 2016. The statistics are not limited to adults, though. Childhood obesity is also on the rise, setting the stage for a lifetime of health challenges.

woman training on semaglutide
Exercise is key to pair with fasting and Semaglutide

The Physiological Effects of Being Overweight

Carrying excess weight can strain your cardiovascular system, leading to conditions such as hypertension, heart disease, and stroke. It can also increase the risk of type 2 diabetes, as well as various cancers, including breast, colon, and liver cancer. Obesity can put additional stress on your joints, contributing to conditions like osteoarthritis and limiting your mobility.

Furthermore, obesity is closely linked to sleep apnea, a condition characterized by interrupted breathing during sleep, leading to fatigue and daytime drowsiness. The accumulation of visceral fat – fat stored deep within the abdominal cavity – can disrupt the balance of hormones responsible for appetite regulation and metabolism, making weight loss difficult.

The Emotional & Mental Effects of Being Overweight

While the physical consequences of obesity are undeniable, the emotional and mental toll is equally significant. Many individuals struggling with excess weight face discrimination and societal bias, leading to feelings of shame, low self-esteem, and even depression. The constant battle with body image can erode self-confidence and hinder social interactions.

Furthermore, the frustration of failed weight-loss attempts can lead to a cycle of emotional eating, exacerbating the problem. The mental strain of obesity can impact relationships, career opportunities, and overall quality of life. It’s essential to recognize that the journey to weight loss isn’t just about shedding pounds; it’s about reclaiming one’s physical and emotional well-being.

The Science Behind Weight Loss

In a world inundated with weight-loss gurus, online influencers, and scam artists, it’s easy to become overwhelmed by the myriad of complicated and often contradictory weight-loss plans they peddle. These individuals often tout “revolutionary” techniques, mystical ingredients, and elaborate routines, all designed to captivate your attention and drain your wallet. The truth, however, is far simpler—you simply need to maintain a calorie deficit.

Cutting Through the Noise

The weight-loss industry is a multi-billion-dollar behemoth with countless products, programs, and strategies vying for your attention. From detox teas to obscure superfoods, it’s easy to be lured into believing there’s a magical shortcut to shedding pounds. Scammers exploit this desire for quick fixes and prey on vulnerability, promising miraculous results that are too good to be true.

But here’s the unvarnished reality: the science of weight loss is grounded in a basic principle of thermodynamics—calories in versus calories out. To lose weight, you must consistently consume fewer calories than your body expends. It’s a fundamental law of energy balance and no amount of pseudoscience or marketing gimmicks can alter this fact.

Why Maintaining A Calorie Deficit Is Hard

Maintaining a calorie deficit means you’re burning more energy than you’re taking in through your diet. Your body then taps into stored fat as a source of energy, leading to weight loss. Achieving a calorie deficit can be done in several ways, including reducing your food intake, increasing physical activity, or a combination of both.

While the concept is simple, the execution can be challenging. It requires discipline, consistency, and a realistic approach. Crash diets and extreme workouts might yield rapid initial results, but they’re rarely sustainable in the long run and can even harm your health. Medications like Semaglutide allow you to safely and sustainably maintain a calorie deficit for extended periods.

Semaglutide: A Game-Changer in Weight Loss

Semaglutide is not just another fad or a fleeting trend. It’s a groundbreaking pharmaceutical innovation that offers hope to individuals struggling with obesity or being overweight. Even if you’re not overweight, it allows you to lose excess weight and maintain a healthy weight. At its core, semaglutide belongs to a class of medications known as GLP-1 receptor agonists, primarily used for managing type 2 diabetes. However, its remarkable effects on weight loss have taken center stage, earning it the reputation of a game-changer in the fight against weight.

Semaglutide works by mimicking the action of a natural hormone called glucagon-like peptide-1 (GLP-1), which plays a crucial role in regulating blood sugar levels and appetite. It activates the GLP-1 receptor in the brain, signaling feelings of fullness and satisfaction. This dual action on blood sugar and appetite makes semaglutide a formidable weapon against obesity, offering a holistic approach to weight management that sets it apart from traditional weight-loss methods. With its potential to address both the physiological and behavioral aspects of overeating, Semaglutide allows you to stick to your low-calorie diet without temptations.

bowl of food that can help with semaglutide
It’s important to eat whole foods and plenty of protein while focusing on weight loss while on Semaglutide.

Key Benefits of Semaglutide for Weight Loss:

  • Significant and sustained weight loss
  • Improved glycemic control
  • Reduction in cardiovascular risk factors
  • Enhanced insulin sensitivity
  • Decreased appetite and calorie intake
  • Potential for long-term weight maintenance
  • Positive impact on obesity-related comorbidities
  • Non-invasive treatment option
  • Evidence-based results from clinical trials

The Science Behind Semaglutide for Weight Loss

Semaglutide belongs to the class of GLP-1 receptor agonists, synthetic compounds that mimic the action of a naturally occurring hormone called glucagon-like peptide-1 (GLP-1).

When administered, Semaglutide activates the GLP-1 receptors in the brain which play a pivotal role in appetite regulation. This results in reduced hunger and increased feelings of fullness, helping individuals consume fewer calories. Simultaneously, Semaglutide influences the gastrointestinal tract, slowing down the emptying of the stomach and reducing the absorption of glucose from food. This dual action effectively lowers calorie intake and blood sugar levels.

Semaglutide’s unique ability to target both the brain and the gastrointestinal system is a key factor in its success as a weight-loss medication. By bridging the brain-gut axis, Semaglutide helps regulate appetite and satiety, creating a sense of control over cravings and the impulse to overeat. This dual approach sets it apart from many weight-loss interventions which often focus solely on calorie restriction or increased physical activity.

Beyond appetite regulation, Semaglutide induces various metabolic changes that contribute to weight loss. It enhances insulin sensitivity, which aids in better utilization of glucose by the body’s cells and reduces the risk of insulin resistance associated with obesity. Semaglutide also promotes the breakdown of stored fat for energy, further contributing to weight loss while preserving lean body mass. These metabolic shifts, combined with reduced calorie intake and improved glycemic control, create a potent formula for sustainable weight loss.

The Weight-Loss Results With Semaglutide

The STEP (Semaglutide Treatment Effect in People with Obesity) trial is a landmark clinical trial that demonstrated the substantial weight-loss potential of Semaglutide. During the STEP trial, participants were administered Semaglutide at a dosage of 2.4 mg once a week for 68 weeks. The results were nothing short of remarkable. On average, individuals in the Semaglutide group experienced a weight loss of approximately 15% of their initial body weight.

To put this into perspective, if someone initially weighed 220 pounds, they could expect to shed around 33 pounds with the help of Semaglutide. This level of weight loss is nearly impossible to achieve or maintain through diet and exercise alone. Moreover, these results were noticeable relatively early in the treatment with substantial weight loss observed within the first few months. Semaglutide’s ability to deliver consistent and significant weight loss has raised hope for individuals seeking sustainable solutions in weight management.

ShedRx: Your Path to Semaglutide for Weight Loss

At ShedRx, we understand that embarking on a weight-loss journey can be overwhelming and that’s why we’re here to guide you every step of the way. With personalized virtual consultations, we connect you with experienced healthcare providers who will assess your individual needs and goals. Once you’ve consulted with our healthcare provider, if deemed suitable, you’ll receive a prescription for Semaglutide injections or lozenges. To enhance your weight-loss journey, we can also provide you with additional weight-loss supplements tailored to your specific needs.

Convenience is key, which is why we deliver your prescribed medications and supplements right to your doorstep. ShedRx is committed to your success, providing the tools, support, and guidance you need to achieve your weight-loss goals. If you’re ready to take the first step towards a healthier you, schedule a consultation with us today.

Semaglutide helps to curb appetite and gain control over cravings to aid weight loss.

ShedRx

Related Topics

We are fully committed to supporting your weight-loss journey and we’re looking forward to offering a range of effective alternative options to help you reach your goals. Here’s how we are managing the FDA’s recent communication and how you can transition to these other effective and affordable options.

What’s Happening with Tirzepatide?

The FDA has issued a letter on the availability of compounded tirzepatide injections. As a result, compounded tirzepatide injections will soon no longer be available. ShedRx has always been aware of this outcome and has been vigorously preparing alternative programs and medications to ensure a smooth transition for you.

We will continue to offer compounded tirzepatide injections through March 19, 2025 and are here to help you transition smoothly to other proven weight-loss medications in the meantime.

Your Treatment Options

We understand how important your health is. To ease the transition, we are offering 20% off your first month of Tirzepatide Liquid Drops if you switch to this option! This is an oral administration of tirzepatide and is an effective alternative to help you along your weight-loss journey. Additionally, here are other your other options as you transition off of tirzepatide injections:

  • Injectable Compounded Semaglutide: Similar to tirzepatide, compounded semaglutide will provide you with similar benefits and results with an easy, once-weekly injection. 
  • Semaglutide Liquid Drops: Enjoy the benefits of GLP-1 medication without needles, thanks to our compounded oral semaglutide.
  • Tirzepatide Liquid Drops: Enjoy the benefits of tirzepatide without needles, thanks to our compounded oral tirzepatide. These will continue to be available indefinitely and are a great alternative to injectable tirzepatide.
  • Brand Name Medications: We will soon offer brand name medications such as Mounjaro, Wegovy, Ozempic, and Rybelsus.
Semaglutide Liquid Drops and Tirzepatide Liquid Drops just dropped! They provide and easy, convenient way to take weight-loss medication without needles.
Semaglutide Liquid Drops and Tirzepatide Liquid Drops just dropped! They provide and easy, convenient way to take weight-loss medication without needles.
Semaglutide Liquid Drops and Tirzepatide Liquid Drops just dropped! They provide and easy, convenient way to take weight-loss medication without needles.
Semaglutide Liquid Drops and Tirzepatide Liquid Drops just dropped! They provide and easy, convenient way to take weight-loss medication without needles.

How to Switch Your Treatment

Please note you do not need to transition from your tirzepatide injections today. We do encourage you to consider what your preference will be. Switching is simple and we’re here to help every step of the way. There are two simple ways to go about this:

  • Schedule a follow-up visit with a licensed provider from your Patient Portal. Navigate to the “Schedule” tab along the top menu and book a time to discuss a program change, OR
  • Reach out to the Care Team by emailing support@shedrx.com or texting them at 833-658-7433 to request a program change.

FAQs:

Why is tirzepatide being phased out?

The FDA has updated guidelines which impact the availability of compounded tirzepatide. All companies that currently offer compounded tirzepatide are being required to phase out the availability of the drug to their consumers.

Will I still get results with other options?

Yes! Tirzepatide Liquid Drops are compounded using SubMagna™. This ensures that tirzepatide retains its efficacy when compounded in this liquid vehicle.

How long do I have to make the switch?

We will continue to offer compounded tirzepatide injections until March 19, 2025. Leading up to that date, you will be prompted by our team to make a decision about what your preferred new method of treatment will be following March 19.

Hi, I’m Beth! I’m a certified health coach and group personal trainer with over a decade of experience. I specialize in nutrition and have carved out a unique niche in medical weight loss, creating tailored, effective plans that deliver real results. My approach focuses not only on achieving short-term goals, but also on building lasting health and longevity for my clients. My expertise and strategic guidance provide a clear, sustainable path to a healthier life. I hope the following will help you to do just that!

Beth, a ShedRx health coach
Beth, a ShedRx health coach

The holidays are a time of joy and celebration, but they can also bring extra demands on our time and energy. With the busy social events, festive meals, and family gatherings, it’s natural for routines to be tested. If you’re on a GLP-1 weight-loss journey, it can feel especially challenging to prioritize workouts, healthy meals, and consistency with your goals. The fun of the season combined with the allure of delicious holiday treats may make it feel like staying on track requires extra effort. 

Here’s the good news: With a little planning and creativity, you don’t have to let the holiday bustle throw you off course. It’s absolutely possible to embrace the holidays while staying aligned with your goals. Here are some tips to help you enjoy the season without compromising your progress:

1. Incorporate Movement Throughout the Day

You don’t need to carve out hours at the gym each day to stay active during the holidays. Try splitting up your movement—morning stretches, a walk at lunch, and some light yoga in the evening can do wonders. Even if you’re on a tight schedule, simple steps like taking the stairs instead of the elevator can add up quickly. Movement is about consistency, not duration, so make it a habit that fits naturally into your day.

Quick Tip: Set a timer every couple of hours to remind yourself to take a 5-minute break and move your body, whether it’s a quick walk or some light stretching!

2. Meal Prep Like a Pro

Holiday meals and treats can quickly throw off your healthy eating, but a little preparation can make all the difference. Dedicate some time each week to prepare your meals so healthy options are always within arm’s reach. Stock up on grab-and-go snacks like chopped veggies, boiled eggs, or protein shakes to resist temptation when hunger strikes. When nutritious food is ready to grab, you’re less likely to fall into the trap of unhealthy choices.

Quick Tip: Block off an hour on Sundays to batch-cook your meals and snacks and organize them in individual containers. That way, you can enjoy nutritious meals without scrambling during the week!

3. Prioritize Protein

Feeling full and satisfied makes it easier to avoid overindulging in holiday sweets. Make protein a priority in every meal and snack which helps maintain stable blood sugar levels and keeps cravings in check. Whether it’s a turkey lettuce wrap, a protein shake, or a grilled chicken salad, protein should take center stage in your holiday meals to help you feel satisfied and energized throughout the day.

Quick Tip: Pack a handful of protein-rich snacks like roasted chickpeas or a protein bar in your bag to keep hunger at bay and stay on track.

4. Create Small Rituals to Stay Grounded

Even in the excitement of the holidays, creating small rituals can help you stay focused on your goals. Whether it’s a 5-minute morning meditation or an evening stretching routine, these rituals serve as reminders of what’s important. Even a few minutes of mindful breathing or stretching can reset your energy, making it easier to stay on track with your wellness goals.

Quick Tip: Set a daily alarm for a 3-minute “wellness break” to give your mind and body the attention it needs.

You don’t have to let the holiday business ruin your progress. It’s totally possible to celebrate while staying on track with your goals.
You don’t have to let the holiday business ruin your progress. It’s totally possible to celebrate while staying on track with your goals.

5. Hydrate with Purpose

Holiday beverages like hot chocolate, eggnog, and festive cocktails can sneak extra calories and sugar into your diet. Make sure you’re staying hydrated by drinking plenty of water throughout the day. Alternating between your holiday drinks and water will help balance out the extra sugar and keep your energy steady. Hydration is key to maintaining focus, reducing cravings, and supporting overall wellness.

Quick Tip: Carry a reusable water bottle with you everywhere you go and drink a full glass of water before indulging in any holiday beverages.

6. Get Creative with Healthier Versions of Treats

Indulging in holiday treats doesn’t mean you have to derail your progress. There are plenty of healthy alternatives that can satisfy your sweet tooth. Try baking cookies with almond flour or using natural sweeteners like stevia or monk fruit for a lower-carb dessert. Look for ways to make your favorite holiday treats work for your health goals, without feeling deprived.

Quick Tip: Make your holiday desserts using ingredients like almond flour or coconut flour to create delicious, lower-carb alternatives that taste just as festive!

7. Stay Engaged with Your Support Circle

Having a support system during the holidays is a game changer. Connect with a friend, family member, or health coach who understands your health journey. Whether it’s through text messages, social media check-ins, or meal-sharing ideas, staying connected will keep you motivated to stay on track, even when things get busy.

Quick Tip: Schedule weekly check-ins with your accountability buddy to share victories and challenges, keeping the holiday joy front and center.

8. Practice Self-Compassion

The holidays are meant to be a time of joy, not perfection. There will be moments when things don’t go as planned, whether it’s skipping a workout or indulging in an extra cookie. Instead of feeling guilty, remember your journey is about progress, not perfection. Embrace the holidays with grace and focus on getting back on track with your next meal or movement.

Quick Tip: If you miss a workout or indulge a little too much, don’t stress. Get back to your healthy habits with your next meal. Balance, not perfection, is key!

The holiday season is all about balance and celebrating the memories you make. With small, intentional choices, you can enjoy everything this season has to offer while staying connected to your goals. Remember, it’s your journey, so make the holidays work for you. Here’s to a balanced, joyful season and a bright, strong year ahead!

Whether you’re toasting to loved ones, health, Christmas, or simply to living another year, the holidays allow for a special season of celebration. While it’s great to celebrate, it may seem intimidating to harness your health progress amidst the wining and dining. This doesn’t mean you need to remove yourself from the fun with friends and family, though. We’ve concocted some delicious drink ideas for you to enjoy throughout the holidays and all-year long.

Cranberry Orange Mocktail

Ingredients

  • ¼ cup fresh cranberries
  • ½ in piece of fresh ginger thinly sliced
  • 2 oz pure or 100% cranberry juice
  • 1 can orange flavored sparkling water or seltzer
  • 4 orange slices
  • 2 rosemary sprigs
  • Ice

Preparation

  1. Soak ½ of the fresh cranberries in hot water for about 10 minutes.
  2. Drain water from the cranberries. Divide the softened cranberries and ginger slices in half and add to the bottom of 2 low ball or rocks glasses. Muddle with a wooden spoon or a muddler.
  3. Squeeze 1 orange slice over cranberries and ginger in each glass and muddle some more.
  4. Fill the glass with ice. Pour the 1 ounce of cranberry juice in each glass and ½ of the orange sparkling water or seltzer and stir well.
  5. Remove some leaves from the end of rosemary sprigs and thread the fresh cranberries onto the sprig for garnish. Lay on top or in the glass.
  6. Add an orange slice to the glass for garnish.

Ginger Turmeric Shots

Ingredients

  • 4 inch fresh ginger root peeled and grated
  • 4 inch fresh turmeric root peeled and grated or 1 tbsp ground turmeric powder
  • 2 lemons juiced
  • 1 cup fresh orange juice
  • 4 tbsp raw honey

Preparation

  1. Put the grated ginger and turmeric, or just ginger if using ground turmeric powder, into a paper towel or cheesecloth and squeeze liquid into a large glass with a lid (if using ground turmeric, add it directly to the glass).
  2. Add lemon juice, orange juice, and honey to the glass and shake well.
  3. Divide evenly in 4 small jars with lids. Seal tightly.
Don't feel bummed out by calorie-dense beverages. Instead, try out these merry mocktails to feel your best this Christmas.
Don’t feel bummed out by calorie-dense beverages. Instead, try out these merry mocktails to feel your best this Christmas.

Cucumber Mint Cooler

Ingredients:

  • 1/2 cucumber, thinly sliced
  • 4-5 fresh mint leaves
  • 1/2 lime, juiced
  • 1 cup sparkling water
  • Ice cubes
  • Optional: Stevia or monk fruit sweetener to taste

Instructions:

  1. Muddle the cucumber slices and mint leaves in a glass.
  2. Add lime juice and sweetener if desired.
  3. Fill the glass with ice and top with sparkling water.
  4. Stir gently and garnish with a cucumber slice and mint sprig.

Pomegranate Ginger Spritz

Ingredients:

  • 2 tbsp pomegranate juice
  • 1/2 tsp freshly grated ginger
  • 1 cup sparkling water
  • Ice cubes
  • Pomegranate seeds and a lime wedge for garnish

Instructions:

  1. In a glass, combine pomegranate juice and grated ginger.
  2. Add ice cubes and pour in sparkling water.
  3. Stir gently and garnish with pomegranate seeds and a lime wedge.

Tropical Pineapple Refresher

Ingredients:

  • 1/4 cup unsweetened pineapple juice
  • 1/4 cup coconut water
  • 1/2 lime, juiced
  • 1 cup sparkling water
  • Ice cubes
  • Pineapple slice for garnish

Instructions:

  1. Mix pineapple juice, coconut water, and lime juice in a shaker or glass.
  2. Pour over ice in a serving glass.
  3. Top with sparkling water and garnish with mint or a pineapple slice.

Cheers to You

As you quench your thirst with these tasty tries, be proud of yourself for loving you and your body enough to opt for a healthier option. Your tomorrow morning self will thank you. For more health inspo, check out our socials found at ShedRx.com.

Sign up to meet with a ShedRx healthcare provider today and begin working on a healthier you.

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Sign up to meet with a ShedRx healthcare provider today and begin working on a healthier you.